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From209US$ /night
Check-in
11Jan2026Select date
Check-out
12Jan2026Select date
Rooms and Guests2 Guests, 1 Room
Key details

About the Hotel

700 West Main Street, Louisville, Kentucky, United States, 40202
-
Steps from the Waterfront Park
Great
8.7
9.3
/10
4.7
4.6
/5

Rooms with Art

21c Louisville offers 91 rooms preserving former bourbon warehouse history. Options include Atrium Suites with king beds, living areas, and tubs; Corner Suites with four windows overlooking 7th Street, Main Street, and the Ohio River; and the Asleep in the Cyclone artist suite featuring a king platform bed, record player, and hand-selected records. All rooms include 50-55 inch HDTVs, Lavazza coffee, Malin+Goetz toiletries, and original artwork.

Proof on Main

Proof on Main serves Ohio River Valley cuisine led by Kentucky native Executive Chef Cody Stone. The menu features southern and Appalachian-inspired dishes. The lounge houses the 21c Selects Private Barrel Program and is ranked among the top bourbon bars in the country. The culinary team provides tailored catering for events.

Museum & Activities

The hotel features over 9,000 square feet of exhibition space with changing contemporary art installations. Facilities include a 24-hour fitness center, sauna, and steam room. Guests can attend events like the Fork & Bottle dinner series with regional distillers or view performances inspired by current exhibitions. The museum is open 24/7 and free to the public.

Downtown Louisville Location

Located on historic Museum Row in downtown Louisville, the hotel is within a half mile of the Kentucky Museum of Art & Craft, Frazier International History Museum, and Muhammad Ali Center. The free electric ZeroBus stops two roads away, running a circulator route along Main and Market streets past Whiskey Row and Slugger Field.

Services & Events

21c provides laundry service, pet-friendly rooms, and a museum gift shop. The dedicated event staff accommodates meetings for 10-60 people in four private galleries. Wedding services include ceremony and reception spaces with Proof on Main catering. The hotel offers eco-conscious event planning guidance and valet parking with Park & Stay packages.

“21c Museum Hotel Louisville distinguishes itself with an immersive art experience and a prime location near Whiskey Row, blending cultural richness with urban exploration; I particularly appreciate its commitment to sustainability and pet-friendly approach, which caters to modern travelers' values. While minor inconsistencies in bar service might occur, the overall package-from the unique southern cuisine at Proof on Main to the artist-designed rooms-makes it a standout choice in Louisville.”
Hotel logo
Grace WhitmanContent & Editorial Director at Familyhotels
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Choose from a variety of room types

Choose from a wide variety of rooms designed for families, including double rooms, family suites, and rooms with breakfast included
Room Balcony
2 persons
29 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Room
2 persons
31 m² 
1 King-size bed
Shower
Coffee machine
Corner Suite
2 persons
61 m² 
1 King-size bed
Shower
Coffee machine
Deluxe King Suite
2 persons
46 m² 
1 King-size bed
Shower
Coffee machine
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Availability and pricing for your selected dates

Book your family’s getaway in a snap with up-to-date availability and pricing!

Facilities

Each family-friendly hotel provides top-notch amenities for an unforgettable stay with your loved ones

General

  • No smoking on site
  • Free Wi-Fi
  • Parking
  • Safe deposit box
  • 24-hour reception
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • Security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Smoke detectors
  • Electric vehicle charging station
  • Fire extinguishers

Sports & Fitness

  • Fitness centre
  • Yoga class

Guest Parking

  • Cookware/ Kitchen utensils

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Outdoor dining area

Business

  • Business centre
  • Meeting/ Banquet facilities
  • Fax/Photocopying

Children

  • Cots

Spa & Leisure

  • Spa & wellness centre
  • Sauna
  • Turkish bath
  • Steam room
  • Full body massage

Room features

  • Air conditioning
  • Heating
  • Mini-bar
  • Soundproofed rooms
  • Patio
  • Tea and coffee facilities
  • Ironing facilities

Bathroom

  • Free toiletries

Self-catering

  • Cookware/ Kitchen utensils

Media

  • Flat-screen TV

Room decor

  • Carpeted floor
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Dining Onsite

At 21C Museum Hotel Louisville, dining unfolds a tapestry of modern American cuisine that invites guests to savor local craftsmanship. The inviting ambience complements the creative flavors, making it a perfect setting for both casual indulgence and memorable gatherings.
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo
21C Museum Hotel Louisville Restaurant photo

Proof on Main

American
Ambiance
Modern environment that effortlessly blends art and dining, creating a vibrant setting that feels both upscale and inviting.
Key Offerings
Signature dishes highlight regional ingredients, while the Fork & Bottle dinner series showcases guest distillers and spirits from across the region, including the annual Hog & Barrel dinner featuring the esteemed Pappy Van Winkle.
Reservation
Reservations recommended.
Hours vary.

Location

700 West Main Street, Louisville, Kentucky, United States, 40202
Map view
700 West Main Street, Louisville, Kentucky, United States, 40202
Nearby
Museum
Louisville Slugger Museum & Bat Factory
180 m
Museum
Muhammad Ali Center
280 m
Museum
Kentucky Science Center
140 m
Museum
The Frazier History Museum
260 m
Museum
Kentucky Museum of Art and Craft
70 m
528 W Main St
Evan Williams Bourbon Experience
200 m
Gallery
Flame Run Glass Studio and Gallery
300 m
500 W Main St
The Belvedere
250 m
Night club
Jimmy Can't Dance
90 m
801 W Main St
Michter's Fort Nelson Distillery
150 m
Library
Sons of the American Revolution Genealogical Research Library
190 m
120 N 10th St
Kentucky Peerless Distilling Co
480 m
401 W River Rd
Belle of Louisville Riverboats
580 m
Restaurants
Proof On Main
10 m
702 West Main Street
Mussel & Burger Bar Downtown
60 m
113 S 7th St Located in Louisville's Central Business District
Bristol Bar & Grille
110 m
614 W Main St
Atlantic No. 5
160 m
605 W Main St Located in Louisville's Central Business District.
Los Aztecas Mexican Restaurant
180 m
445 E Market St
Vincenzo's Italian Restaurant
430 m
150 S 5th St
Jockey Silks Bourbon Bar
480 m
140 N 4th St 2nd Floor - West Tower
Dish on Market
470 m
434 W Market St
Quiznos
540 m
223 S 5th St
Swizzle Dinner & Drinks
530 m
140 N Fourth St 25th Floor
Cafe Magnolia
590 m
140 N 4th St Galt House Hotel
Explore Louisville
Explore Louisville
Top Attractions
Activities
Dining
Entertainment
Kentucky Science Center
Kentucky Science Center
2 minutes walking
Hands-on exhibits for all ages focus on science and technology, with IMAX films and live demonstrations.
Muhammad Ali Center
Muhammad Ali Center
4 minutes walking
A museum honoring Muhammad Ali's legacy, featuring interactive exhibits and film presentations about his life and values.
Louisville Slugger Museum & Bat Factory
Louisville Slugger Museum & Bat Factory
3 minutes walking
Home of the iconic baseball bat, with factory tours and memorabilia dedicated to baseball history.
Waterfront Park
Waterfront Park
17 minutes walking
A scenic riverside park with trails, picnic areas and views of the Ohio River, perfect for outdoor activities.
Urban Kayaking
5 minutes driving
Rent kayaks for a thrilling paddle on the Ohio River, with options for guided tours available.
Yoga on the Waterfront
17 minutes walking
Relaxing outdoor yoga sessions held at Waterfront Park, offering tranquility amidst nature.
Proof On Main
Proof On Main
1 minute walking
A fine dining experience featuring locally sourced dishes, unique artwork, and an extensive bourbon selection.
Mussel & Burger Bar Downtown
Mussel & Burger Bar Downtown
1 minute walking
Casual eatery known for gourmet burgers and fresh mussels, with a lively atmosphere and craft beer options.
KFC Yum Center
KFC Yum Center
9 minutes walking
Major venue for concerts and sports events, featuring a vibrant atmosphere and diverse programming.
Fourth Street Live!
10 minutes walking
An energetic entertainment district with live music, bars, and dining options, perfect for nightlife enthusiasts.
Tips on navigating the city
City Centre
Louisville23 min  ·  1.9 km
Airports
Louisville International Airport (SDF)18 min  ·  11.9 km
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Check Rates
Property information and rules
Check-in
from 16:00-23:59
Check-out
until 11 am
Guest Parking
No parking available.
Internet
is available in for free.
Children & extra beds
Maximum capacity of extra beds in a room is 1. 
Pets
Pets are allowed on request.
Year renovated:
2006
Number of floors:
4
Number of rooms:
96
Former name
21c Museum Hotel
FAQs
About 21C Museum Hotel Louisville
What attractions are within walking distance from 21C Museum Hotel Louisville?
Nearby attractions include the Muhammad Ali Center (0.5 km), the Louisville Slugger Museum & Factory (0.5 km), and the Kentucky Museum of Art & Craft (1 km).
What time can I check in and check out at 21C Museum Hotel Louisville?
Check-in is at 16:00 and check-out is by 11:00.
Is parking available at 21C Museum Hotel Louisville?
Valet parking services are offered at the hotel.
What fitness facilities are available at 21C Museum Hotel Louisville?
Guests have access to a 24-hour fitness center and spa services, including a sauna and steam room.
What room amenities can I expect at 21C Museum Hotel Louisville?
Rooms feature free Wi-Fi, a 50-inch flat-screen cable TV, a minibar, and premium sleep beds.
What dining options are available at 21C Museum Hotel Louisville?
The hotel features an on-site restaurant, Proof on Main, which offers a menu focusing on southern cuisine.
How far is 21C Museum Hotel Louisville from Louisville International Airport?
The hotel is located 10 km from Louisville International Airport, which is approximately a 15-minute drive.
Does 21C Museum Hotel Louisville offer business services?
The hotel provides a business center and meeting facilities suitable for corporate events.
What is unique about the rooms at 21C Museum Hotel Louisville?
Rooms are designed with contemporary art installations, offering a unique aesthetic experience.
What nearby restaurants can I find around 21C Museum Hotel Louisville?
Nearby restaurants include Atlantic No. 5, Morton's The Steakhouse, and Mussel & Burger Bar, all within 0.5 km.
Are there any spa services available at 21C Museum Hotel Louisville?
The on-site spa offers a range of services including massages, a sauna, and wellness therapies.

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